whether there's any difference with the new Niaspan tablets

We're getting questions about whether there's any difference with the new Niaspan tablets.

The new orange tabs are film-coated to make them easier to swallow.

The only significant change is that the 1000 mg tabs are now reformulated to slow absorption.

Most people didn't realize that the old 1000 mg tabs were absorbed faster than the other strengths. This meant that the old 1000 mg tab was not bioequivalent to two 500 mg tabs.

Now both strengths are absorbed at the same rate.

The manufacturer is hoping that the slower absorption will also reduce flushing...but this isn't proven so far.

Some people cite a small study showing modestly less flushing after a 2 g dose of the new tabs. But most patients still flush.

And there's no proof the new tabs will be better tolerated after titrating the dose...or with chronic use.

Continue counseling patients to take aspirin 30 minutes before Niaspan if needed to help prevent flushing.

• Other: New Niaspan Formulation