metabolic acidosis in patients taking the antiepileptic, zonisamide (Zonegran, etc)

April 2009

You'll see a new warning about metabolic acidosis in patients taking the antiepileptic, zonisamide (Zonegran, etc).

This is similar to the warning about metabolic acidosis with topiramate (Topamax, etc).

Zonisamide and topiramate are carbonic anhydrase inhibitors. This increases bicarb excretion and can lead to metabolic acidosis.

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Table of Contents

proton pump inhibitors (PPIs) might DECREASE the efficacy of clopidogrel (Plavix)
Antithrombotics when and how to use vitamin K to reverse the effects of warfarin
Cardiology whether it's HARMFUL to combine an ACE inhibitor and ARB
Psychiatry how to treat dementia associated with Parkinson's
Psychiatry metabolic acidosis in patients taking the antiepileptic, zonisamide (Zonegran, etc)
Respiratory & Allergy Symbicort (budesonide/formoterol) will be used more for COPD
Respiratory & Allergy patients on Afrin or other nasal decongestants get rebound congestion
Gastroenterology Metoclopramide will have a new black box warning about the risk for tardive dyskinesia
Pediatrics Miralax is being used more to treat constipation in kids
Diabetes controversy about using glyburide for type 2 diabetes
Shortages alternatives to oxycodone
Infectious Diseases LESS cross-sensitivity between penicillins and carbapenems than most clinicians think
Gout Uloric (YOU-lor-ik, febuxostat) is the first new chronic treatment for gout in over 40 years